Réseau en Santé Respiratoire du Québec

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Fibrose kystique

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Publications

Antioxidants in cystic fibrosis. Conclusions from the CF antioxidant workshop, Bethesda, Maryland, November 11-12, 2003.

AM Cantin, TB White, CE Cross, H Jay-Forman, RJ Sokol, D Borowitz.
Thorax, 2007, 42 (1): 15-31

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CFTR silencing in Pancreatic Beta-Cells Reveals a Functional Impact on Glucose- Stimulated Insulin Secretion and Oxidative Stress Response.

T NTimbane, Mailhot G, Spahis S, Rabasa-Lhoret R, Kleme ML, Melloul D, Brochiero E, Berthiaume Y, Levy E.
Am J Physiol Endocrinol Metab., 2016, 2016 Feb 1;310(3):E200-12

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Cholesterol modulates CFTR confinement in the plasma membrane of primary epithelial cells.

A Abu-Arish , Pandzic E, Goepp J, Matthes E, Hanrahan JW, Wiseman PW.
Biophys J., 2015, 2015 Jul 7;109(1):85-94.

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Clinical outcomes associated with Pseudomonas aeruginosa and Staphylococcus aureus airway infections in adult cystic fibrosis patients.

HG Ahlgren, Benedetti A, Landry JS, Bernier J, Matouk E, Radzioch D, Lands LC, Rousseau S, and Nguyen D.
BMC Pulm Med. , 2015, 2015 Jun 21;15:67.

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Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium.

L Freschi, Jeukens J, Kukavica-Ibrulj I, Boyle B, Dupont MJ, Laroche J, Larose S, Maaroufi H, Fothergill JL, Moore M, Winsor GL, Aaron SD, Barbeau J, Bell SC, Burns JL, Camara M, Cantin A, Charette SJ, Dewar K, Déziel É, Grimwood K, Hancock RE, Harrison JJ, Heeb S, Jelsbak L, Jia B, Kenna DT, Kidd TJ, Klockgether J, Lam JS, Lamont IL, Lewenza S, Loman N, Malouin F, Manos J, McArthur AG, McKeown J, Milot J, Naghra H, Nguyen D, Pereira SK, Perron GG, Pirnay JP, Rainey PB, Rousseau S, Santos PM, Stephenson A, Taylor V, Turton JF, Waglechner N, Williams P, Thrane SW, Wright GD, Brinkman FS, Tucker NP, Tümmler B, Winstanley C, Levesque RC.
Front Microbiol. , 2015, 2015 Sep 29;6:1036.

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Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection.

I Bianconi, Jeukens J, Freschi L, Alcalá-Franco B, Facchini M, Boyle B, Molinaro A, Kukavica-Ibrulj I, Tümmler B, Levesque RC, Bragonzi A.
BMC Genomics, 2015, 2015 Dec 29;16(1):1105.

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Complex two gene modulation of lung disease severity in children with cystic fibrosis.

R Dorfman, A Sandford, C Taylor, B Huang, D Frangolias, Y Wang, R Sang, L Pereira, L Sun, Y Berthiaume, L Tsui, PD Paré, P Durie, M Corey, J Zielenski.
JCI, 2008, In press

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Cystic fibrosis-adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyper-inflammatory responses

S Lafayette, Houle D, Beaudoin T, Wojewodka G, Radzioch D Hoffman LR, Burns JL, Dandekar A, Smalley N, Chandler J, Zlosnik J, Speert D, Bernier J, Matouk E, Brochiero E, Rousseau S, Nguyen D.
Sci Adv., 2015, 2015 Jul;1(6)

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Deleterious impact of hyperglycemia on cystic fibrosis airway ion transport and epithelial repair.

C Bilodeau, Bardou O, Maillé É, Berthiaume Y, Brochiero E.
J Cyst Fibros, 2016, 2016 Jan;15(1):43-51.

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Deleterious impact of Pseudomonas aeruginosa on cystic fibrosis transmembrane conductance regulator function and rescue in airway epithelial cells.

NT Trinh, Bilodeau C, Maillé É, Ruffin M, Quintal MC, Desrosiers MY, Rousseau S, Brochiero E.
Eur Resp J, 2015, 2015 Jun;45(6):1590-602

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Differential contribution of the Aryl-Hydrocarbon Receptor and Toll-Like Receptor Pathways to IL-8 expression in normal and cystic fibrosis airway epithelial cells exposed to Pseudomonas aeruginosa.

L Roussel, LaFayette S., Nguyen D., Baglole CJ and Rousseau S
Front. Cell Dev. Biol. , 2016, 4:148. doi: 10.3389/fcell.2016.00148

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Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1.

N Dauletbaev, Herscovitch K, Das M, Chen H, Bernier J, Matouk E, Bérubé J, Rousseau S, Lands LC.
Br J Pharmacol. , 2015, 2015 Oct;172(19):4757-71.

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Draft Genome Sequence of Triclosan-Resistant Cystic Fibrosis Isolate Achromobacter xylosoxidans CF304.

J Jeukens, Freschi L, Kukavica-Ibrulj I, Nguyen D, Levesque RC.
Genome Announc., 2015, 2015 Jul 30;3(4).

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Essential genes in the infection model of Pseudomonas aeruginosa-PCR-based signature-tagged mutagenesis.

I Kukavica-Ibrulj , Levesque RC.
Methods Mol Biol. , 2015, 2015;1279:97-123.

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Fenretinide corrects newly found ceramide deficiency in cystic fibrosis.

C Guilbault, JB De Sanctis, G Wojewodka, Z Saeed, C Lachance, TA Skinner, RM Vilela, S Kubow, LC Lands, M Hajduch, E Matouk, D Radzioch.
Am J Respir Cell Mol Biol, 2008, 38 (1): 47-56,

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Genes Required for Free Phage Production are Essential for Pseudomonas aeruginosa Chronic Lung Infections.

LL Lemieux, Jeukens J, Kukavica-Ibrulj I, Fothergill, J.A, Boyle B, Laroche J, Tucker, N.P., Winstanley C, Levesque, RC.
J Infect Dis, 2015, 2015; 213 (3), 395-402.

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High-dose Ibuprofen in cystic fibrosis: Canadian safety and effectiveness trial.

LC Lands, R Milner, AM Cantin, D Manson, M Corey.
J Pediatr, 2007, 151(3): 249-254

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Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.

GW Carlile, Robert R, Goepp J, Matthes E, Liao J, Kus B, Macknight SD, Rotin D, Hanrahan JW, Thomas DY.
J Cyst Fibros, 2015, 2015; 14(1):16-25.

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Increased C-Reactive Protein levels in stable adult cystic fibrosis patients are associated with worse clinical variables and a higher risk of future pulmonary exacerbations: an observational cohort study.

E Matouk, Nguyen D., Benedetti A., Bernier J., Gruber J., Landry J., Rousseau S., Ahlgren H., Lands L., Wojewodka G and Radzioch D
BMC Pulmonary Medicine, 2016, In press

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Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy.

AM Cantin, Hartl D, Konstan MW, Chmiel JF.
J Cyst Fibros. , 2015, 2015 Jul;14(4):419-30.

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Interspecific small molecule interactions between clinical isolates of Pseudomonas aeruginosa and Staphylococcus aureus from adult cystic fibrosis patients.

A Fugère, Lalonde Séguin D, Mitchell G, Déziel E, Dekimpe V, Cantin AM, Frost E, Malouin F.
PLoS ONE, 2014, 2014 Jan 23;9(1):e86705. doi: 10.1371/journal.pone.0086705.

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Investigating CFTR and KCa3.1 Protein/Protein Interactions.

H Klein, Abu-Arish A, Trinh NT, Luo Y, Wiseman PW, Hanrahan JW, Brochiero E, Sauvé R.
PLoS ONE, 2016, 2016 Apr 19;11(4):e0153665. doi: 10.1371/journal.pone.0153665.

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Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.

GW Carlile, Robert R, Matthes E, Yang Q, Solari R, Hatley R, Edge CM, Hanrahan JW, Andersen R, Thomas DY, Birault V.
Mol Pharmacol, 2016, 2016 Aug;90(2):65-79. doi: 10.1124/mol.115.102418.

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Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor).

E Matthes, Goepp J, Carlile GW, Luo Y, Dejgaard K, Billet A, Robert R, Thomas DY, Hanrahan JW.
Br J Pharmacol, 2016, 2016 Feb;173(3):459-70. doi: 10.1111/bph.13365.

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Molybdate transporter ModABC is important for Pseudomonas aeruginosa chronic lung infection.

S Périnet, Jeukens J, Kukavica-Ibrulj I, Ouellet M, Charette S, Levesque RC.
BMC Research Notes, 2016, 2016; 9 (1), 23.

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Neutrophils mediate airway hyperresponsiveness after chlorine-induced airway injury in the mouse.

TK McGovern, Goldberger M, Allard B, Farahnak S, Hamamoto Y, O'Sullivan M, Hirota N, Martel G, Rousseau S, Martin JG.
Am J Respir Cell Mol Biol, 2015, 2015 Apr;52(4):513-22.

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Nutrition in pediatric lung disease

LC Lands,
Pediatr Res, 2007, Rev 8 (4): 305-312

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Oxidative stress, smoking and CFTR: can cystic fibrosis be acquired?

C Ouellet, G Bilodeau, AM Cantin.
Médecine sciences, 2007, 23 (1): 9-10

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Persistent osteopenia in adult cystic fibrosis transmembrane conductance regulator-deficient mice.

CK Haston, W Li, A Li, M Lafleur, JE Henderson.
Am J Respir Crit Care Med, 2008, 177 (3): 309-15

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Proresolving Action of Docosahexaenoic Acid Monoglyceride in Lung Inflammatory Models Related to Cystic Fibrosis.

C Morin, Cantin AM, Rousseau É, Sirois M, Sirois C, Rizcallah E, Fortin S
Am J Physiol Lung Cell Mol Physiol, 2015, 2015 Oct;53(4):574-83.

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Quorum sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair.

M Ruffin, Bilodeau C, Maillé E, Lafayette S, McKay G, Trinh NTN, Beaudoin T, Desrosiers M-Y, Rousseau S, Nguyen D, Brochiero E.
Faseb J. , 2016, 30(9): 3011-3025, 2016. IF 5.04.

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Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation.

A Billet, Jia Y, Jensen T, Riordan JR, Hanrahan JW.
FASEB J., 2015, 2015 Sep;29(9):3945-53.

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Rhinovirus Load Is High despite Preserved Interferon-β Response in Cystic Fibrosis Bronchial Epithelial Cells.

N Dauletbaev, Das M, Cammisano M, Chen H, Singh S, Kooi C, Leigh R, Beaudoin T, Rousseau S, Lands LC.
PLoS ONE, 2015, 2015 Nov 23;10(11):e0143129.

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Staphylococcus aureus Inhibits IL-8 Responses Induced by Pseudomonas aeruginosa in Airway Epithelial Cells.

SM Chekabab, Silverman R, LaFayette S, Luo Y, Rousseau S, and Nguyen D.
PLoS ONE, 2015, 2015 Sep 11;10(9):e0137753.

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Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-β in Airway Epithelial Cells with Minimal Costimulation of IL-8.

N Dauletbaev, Cammisano M, Herscovitch K, Lands LC.
J. Immunol., 2015, 2015 Sep 15;195(6):2829-41.

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Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect.

R Robert, GW Carlile, C Pavel, N Liu, SM Anjos, J Liao, Y Luo, D Zhang, DY Thomas, JW Hanrahan.
Mol Pharmacol, 2008, 73:478-489, 2008.

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The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia.

MJ Turner, Matthes E, Billet A, Ferguson AJ, Thomas DY, Randell SH, Ostrowski LE, Abbott-Banner K, Hanrahan JW.
Am J Physiol Lung Cell Mol Physiol, 2016, 2016 Jan 1;310(1):L59-70.

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The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection.

H Traboulsi, Cloutier A, Boyapelly K, Bonin MA, Marsault É, Cantin AM, Richter MV
Antimicrob Agents Chemother. , 2015, 2015 Oct;59(10):6317-27.

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